生命科学部
| 2024 年 7 月 18 日
科大团队发现新的细胞因子促进SARS-COV-2进入宿主细胞 为治疗新冠提供新方向
物理系
| 2024 年 6 月 6 日
科大团队提出高频重力波创新探测方法 助探索宇宙奥秘
海洋科学系
| 2024 年 5 月 16 日
科大研究团队分析蓝藻羧酶体自组装原理 为促进光合作用提供新见解
生命科学部
| 2024 年 2 月 20 日
科大成功研发血液测试　精准诊断阿尔茨海默病和轻度认知障碍
数学系
| 2024 年 2 月 2 日
科大团队研发AI模型 能协助减少全球农田氨气排放达38% 有助达成联合国可持续发展目标
In CNS, such as retinal ganglion cells, IFNγ activates STAT1 in Ptpn2 cKO RGCs. STAT1 then upregulates neuronal cGAS expression. cGAS produces cGAMP and activate STING in neurons. In PNS, such as dorsal root ganglion, axotomy induces IFNγ expression in axons by local translation. And IFNγ activates STAT1-cGAS signaling and cGAMP production in surrounding Schwann cells and blood cells, to promote peripheral axon regeneration.
In CNS, such as retinal ganglion cells, IFNγ activates STAT1 in Ptpn2 cKO RGCs. STAT1 then upregulates neuronal cGAS expression. cGAS produces cGAMP and activate STING in neurons. In PNS, such as dorsal root ganglion, axotomy induces IFNγ expression in axons by local translation. And IFNγ activates STAT1-cGAS signaling and cGAMP production in surrounding Schwann cells and blood cells, to promote peripheral axon regeneration.
生命科学
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研究发现促进成年神经系统轴突再生的内在免疫机制

中枢神经系统一旦受创，例如在脊髓损伤的意外中，伤者很可能会永久丧失感觉或活动能力，当中的关键原因，是轴突断裂后无法再生。目前，医学界为脊髓损伤患者恢复活动能力的方法非常有限。若要为他们带来治疗希望，其中一个 研究方向，便是要破解令这些受伤轴突再生的方法。

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Left: the solution is confined by graphene. Right: the solution is confined by stishovite (SiO2). The white, grey, red, and pink balls are the hydrogen, carbon, oxygen, and silicon atoms, respectively.
Left: the solution is confined by graphene. Right: the solution is confined by stishovite (SiO2). The white, grey, red, and pink balls are the hydrogen, carbon, oxygen, and silicon atoms, respectively.
化学
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深部碳揭秘

香港科大的一项最新研究表明，地球内部的CO2可能比之前认识的更加活跃，并在地球气候变化过程中扮演更重要的角色。

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Changes in aging stem cells
Changes in aging stem cells
生命科学
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科大团队破解干细胞变化之谜 为抗衰老研究迈进一大步

古今中外，「抗衰老」一直都是历史和文学中的热门题材。从中国古代的秦始皇派员远征大海寻找长生不死之药，到西方小说中的德古拉伯爵拥有不死之身，千百年来，人类仍沉醉于寻找不老之术，至今仍未有解决方法。

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Prof. Nancy IP (first row second right) and her research team members.
Prof. Nancy IP (first row second right) and her research team members.
生命科学
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科大发现血液蛋白新靶点 开拓治疗阿尔兹海默症新方向

由香港科技大学（科大）晨兴生命科学教授兼香港神经退行性疾病中心主任叶玉如教授领导的国际研究团队，发现了一种在阿尔兹海默症（AD）发病机制中起关键作用的血液蛋白，有助设计创新治疗策略，降低AD发病风险和改善AD患者病况。

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(From left) Prof. Chen Qing and his research group members Dr. Li Liangyu (postdoctoral fellow) and Xiao Diwen (PhD student) at the lab of HKUST Energy Institute. On the lab bench is a set-up for fabricating the nanoporous zinc metal electrode.
(From left) Prof. Chen Qing and his research group members Dr. Li Liangyu (postdoctoral fellow) and Xiao Diwen (PhD student) at the lab of HKUST Energy Institute. On the lab bench is a set-up for fabricating the nanoporous zinc metal electrode.
化学
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科大研发纳米多孔锌电极 即弃碱性锌电池也可充电

香港科技大学（科大）的研究团队成功研制了一款新的电极设计，令日常生活中常见的非充电碱性锌电池变成可充电，有助推动更广泛使用充电池。

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A joint research team from The Hong Kong University of Science and Technology (HKUST), and the LKS Faculty of Medicine, The University of Hong Kong (HKUMed) have demonstrated that ZCB11, a broadly neutralising antibody derived from a local mRNA-vaccinee against the spreading Omicron variants of SARS-CoV-2, displays potent antiviral activities against all variants of concern (VOCs), including the dominantly spreading Omicron BA.1, BA1.1 and BA.2. The research team members include (from left): Professor Dang
A joint research team from The Hong Kong University of Science and Technology (HKUST), and the LKS Faculty of Medicine, The University of Hong Kong (HKUMed) have demonstrated that ZCB11, a broadly neutralising antibody derived from a local mRNA-vaccinee against the spreading Omicron variants of SARS-CoV-2, displays potent antiviral activities against all variants of concern (VOCs), including the dominantly spreading Omicron BA.1, BA1.1 and BA.2. The research team members include (from left): Professor Dang
生命科学
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香港科技大学及港大医学院联合研究证明广谱中和抗体 可保护叙利亚仓鼠免受SARS-CoV-2 Omicron变异株感染

香港科技大学（科大）的结构生物学家联同香港大学艾滋病研究所、香港大学李嘉诚医学院（港大医学院）临床医学学院微生物学系与香港大学新发传染病国家重点实验室的研究人员已证明，源自本地 mRNA 疫苗接种者、针对SARS-CoV-2 Omicron变异株的广谱中和抗体ZCB11，对所有受关注变异株（variants of concern, VOCs）包括当前主要流行的Omicron BA.1、BA.1.1 和 BA.2，均显示出有效的抗病毒活性。

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Geographical location and bathymetry of the South China Sea.
Geographical location and bathymetry of the South China Sea.
海洋科学
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科大研究人员发现南海存在三层交替旋转运动的「热点」源

香港科技大学(科大)港澳海洋研究中心主任甘剑平教授研究团队于中国南海进行海洋模拟试验及观测，透过地球流体动力学理论，揭秘了南海的海洋三维运动特征。

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In vivo 3P calcium imaging of spontaneous neuronal activity at different depths below pia of the somatosensory cortex of a CCK-GCaMP6s mouse (4-month-old) through the intact skull (110-μm thickness) with system correction only (left) and full AO correction (right).
In vivo 3P calcium imaging of spontaneous neuronal activity at different depths below pia of the somatosensory cortex of a CCK-GCaMP6s mouse (4-month-old) through the intact skull (110-μm thickness) with system correction only (left) and full AO correction (right).
生命科学
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科大研究人员在前所未有的深度实现了小鼠大脑皮层近无创活体成像

香港科技大学（科大）的一个研究小组首次实现穿过完整的小鼠头骨在脑膜下方750微米这一前所未有的深度，对小鼠大脑皮层内的微小神经结构進行活体成像。这一研究能够以接近无创的方式在大脑皮层中进行高分辨成像，将进一步促进大脑科学的研究。

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The research team cultivates "mini brains" with stem cell technology to evaluate the patients’ brain reactions to potential drug candidates in developing novel AD treatments.
The research team cultivates "mini brains" with stem cell technology to evaluate the patients’ brain reactions to potential drug candidates in developing novel AD treatments.
生命科学
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科大积极推动神经退行性疾病早期诊断及基因治疗研究

香港神经退行性疾病中心（Hong Kong Center for Neurodegenerative Diseases，简称HKCeND）由香港科技大学（科大）成立，其研究团队在阿尔兹海默症（AD）的早期诊断和治疗方面取得了重大突破，有望为疾病管理带来变革。

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A diagram demonstrating how hedgehog molecules are secreted from the producing cells and received by the target cells to induce the signal transduction pathway in target cells.
A diagram demonstrating how hedgehog molecules are secreted from the producing cells and received by the target cells to induce the signal transduction pathway in target cells.
生命科学
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HKUST-led research reveals a novel molecular mechanism that regulates secretion of sonic hedgehog, shedding light on cancer treatments

A research led by HKUST has revealed a novel mechanism that regulates secretion of sonic hedgehog (Shh), a key signaling molecular that plays an important role in cancer progression, in mammals, opening the door to novel therapeutic strategies for cancer induced by the hedgehog signaling pathway.

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